The crypto city home to biohacking experiments

A general approach that employs technology to enhance the functioning of the human body, biohacking enthusiasts are continuously seeking new ways to optimize their performance. Martin Kremmer, an entrepreneur who became interested in the topic after experiencing burnout, explores his own experiences in biohacking his own diet and lifestyle in pursuit of a longer, healthier life.

Margaret Talbot spotlights the rise of DIY biology in community labs, where amateur scientists—often outside formal institutions—create everything from insulin to prosthetic prototypes. These grassroots biohackers challenge traditional science by pursuing open, accessible innovation, raising questions about credibility, ethical oversight, and acceptance by mainstream researchers.

Biohacking seeks to optimize human health and performance through everything from simple lifestyle adjustments to more radical interventions like body modifications and experimental technology. At its core, biohacking covers a wide spectrum—ranging from improving sleep and focus to implanting devices that integrate technology with the human body.

Biohacking is a broad collection of self-improvement techniques meant to enhance a human's health, lifespan, or ability. There are basic biohacks, like the use of caffeine, and more extreme ones, like under-the-skin implants. The difference between biohacking and standard medicine is that biohacking is primarily a do-it-yourself approach and is mostly unregulated.

Johnson has invested millions of dollars into developing a biohacking program he believes will extend his life beyond typical expectations, relying on medical professionals to reduce his "biological age." Most notably, he drew significant public attention with reports of blood-swapping with his teenage son.

Entrepreneur Dave Asprey wants to live longer than anyone else, a desire that's led him to biohacking. Asprey relies on supplements, stem cell treatments, rigid dieting, exercise, and more. The inventor of Bulletproof Coffee has no medical or nutritional training, though that's not unusual among biohacking's DIY experimenters.

When Andrew Greenstone attended a biohacking conference in Austin, Texas, he didn't expect to walk away a newly implanted member of the techy cadre. Partway through the event, he paid $150 to have an NFC chip inserted into his right hand.

Journalist Adi Robertson experimented with one of the most accessible biohacks: magnets. Having a tiny magnet in their right ring finger meant they could sense magnetic fields, attract small metal objects, and more. But magnets weaken over time, eroding this new sense. Such implants do more than offer a new way of interacting with the world, they also pose new complications, such as the inability to get an MRI.

At companies like Ginkgo Bioworks, researchers are reprogramming cells to act as workshops that can create custom molecules, such as medicines and fertilizers, by stitching together DNA sequences—often in novel combinations—before inserting them into an organism's genome.

Author and entrepreneur Rob Reid reviews the risks of a world where more and more people have access to the technology needed to create a doomsday bug that could wipe out humanity.

If a tree frog was injected with a DNA mixture containing follistatin, a gene that may influence muscle growth, would it become buff? Josiah Zayner hopes so. By learning how to biohack animals, he hopes people are one step closer to feeling more comfortable "whipping up DIY gene therapy."

Built as a futuristic, eco-friendly city filled with smart features like pneumatic trash systems and app-controlled homes, the town provides limited opportunities for face-to-face interactions amid sterile backdrops. A focus on high-rise housing amplifies the lonely, disconnected atmosphere.

The experiments involve populating barren hillslopes within the Landscape Evolution Observatory with microbes that react with air and rock to produce molecules needed by more complex organisms. Mosses and other simple plants can then grow in these spaces, gradually making them more hospitable to humans.

The "Silicon Valley of Hardware" is a major manufacturing hub. This WIRED documentary from 2016 does a deep dive into how this Chinese city's practice of copycat manufacturing alongside its innovative culture has made it China's own Silicon Valley.

Built to establish a self-sustaining habitat, the privately funded facility was taken over by Columbia University in 1995. Closed-system experiments were halted in favor of investigations focused on the effects of climate change, which continued after B2 was donated to the University of Arizona in 2011.

Biohacker Michael Laufer recently had a 512GB drive implanted in his leg, which can store data, stream music or movies, and power a hot spot and mesh network. It's called the PegLeg, and WIRED's Daniel Oberhaus spoke with Laufer about the device and the field of biohacking.

There's always been a divide between technology, the inanimate stuff that we build, and biology, the living stuff that nature builds. Synthetic biologists are trying to figure out how to close the gap by building living things.

Australian start-up Cortical Labs unveiled CL1, a hybrid chip designed to help scientists study brain function in real-time. The 800,000 lab-grown neurons on the chip are kept viable for six months via a built-in life support system.

Created by entrepreneur Bryan Johnson in 2022, the Rejuvenation Olympics asks participants to find ways, including exercise and dietary supplements, to slow their biological aging. But some of these tactics are extreme in cost or nature—such as Johnson's regular injections of blood from his teenage son.

The term "cyborg" was coined in a 1960 academic paper discussing what alterations humans would need to undergo to survive in extraterrestrial environments, a venture far "more logical than providing an earthly environment" in space. According to authors Manfred E. Clynes and Nathan S. Kline, Cyborgs with a capital C have incorporated exogenous components that extend their ability to adapt to new environments. Read the paper here.

Tales of searching for the Fountain of Youth persist. Our modern-day version is marked by promises of pharmaceutical miracles and a proliferation of viral "biohacking" routines. One doctor’s quest to unlock the keys to longevity stimulated much of this renewed fervor, though his ideas are often taken out of context.

Built from 1965 to 1972, the habitat hosted 10 experiments with crews ranging from one to three individuals who had their air recycled by algae and grew their own wheat and vegetables. However, dried meats were routinely brought into the facility to balance crew members’ diets.

These tests claim to show how at-risk a hypothetical baby would be for genetic syndromes. The newfound industry has prompted ethical and medical debates, with critics questioning their accuracy and highlighting the potential problems behind pursuing the perfect baby.

Silicon Valley wasn't supposed to happen. A stretch of California orchard land somehow became the place that built the modern world: chips, PCs, the internet, the smartphone, and now AI. But the real story isn't the garage myth. It's a series of contradictions hiding in plain sight.

An ambitious project launched by OpenAI's founder Sam Altman, Worldcoin aims to provide a global financial and identity network based on proof of personhood through biometric scanning of individuals' irises.

Smart cities require vast troves of data to run, making their systems attractive to hackers. Listen to this one hour podcast to learn about the risks and what is being done to mitigate them.

The research at Biosphere 2 has led to the development of low-cost plant monitors, which can be provided to farmers worldwide to enable more precise monitoring of crops. Geodesic domes built within the ocean biome are used to investigate the best architectural structures for repopulating degraded reefs.

Although different companies have described focuses ranging from luxury tourism to Martian space colonies, all are building infrastructure to capitalize on the shift away from government-only control and betting big on reusability and scale. By securing public contracts and subsidies, they aim to develop strategic partnerships toward dominance in low Earth orbit.

A fascinating look into what makes Singapore one of the smartest cities in the world, including human-centric innovations benefitting human health such as the AI-powered "Smart Elderly Alert System."

The law expands personal privacy protections to include data from brain activity, marking the first legal step of its kind in the US. It targets companies involved in consumer neurotechnologies, which were previously not required to restrict user data access.

The experiments involve identifying conditions needed to grow plants beneath solar panels, which protect the plants from the harsh sunlight of the Arizona desert. Research includes a citizen science component, where satellite gardens have been installed in nearby high schools.

Some argue that isolation from the outside world was compromised—making the experiment a failure—when a crew member was taken from Biosphere 2 for surgery and returned hours later. This position was strengthened when it was revealed that oxygen had been pumped into the facility.

What’s it like to live in a smart city? The BBC interviewed residents of five of the world’s smartest, as determined by the International Institute for Management Development, to find out. (See previous resource for those rankings.) Common praises included ease of transportation, sustainability initiatives and proximity to nature.

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

Los Angeles utilized aerial imaging and cluster analysis to gather and interpret civic data, leveraging surveillance technologies developed by the Department of Defense during the height of the Cold War. Instead of being used for military purposes, data insights helped direct social services to high-poverty neighborhoods.

In 2024, after Polymarket markets favored what turned out to be the winning outcome of the US presidential election, agents raided Coplan's New York City apartment. Coplan, who was only 26 years old at the time, was home during the raid and turned over his devices to authorities.

In 1990, scientists set out to map all of human DNA. A $3B bet many called "junk." But the Human Genome Project's radical transparency and a race with a private company sped it to completion in just 13 years. Today, that once-contested map underpins nearly every breakthrough in genetics and personalized medicine.

Yuegong-1, also known as Moon Palace 1, was a Beijing facility where volunteers simulated life on a colony and conducted experiments on bioregenerative life support systems to assess their viability in an off-Earth environment. The longest experiment at the 0.04-acre facility lasted 370 days.

University of Michigan professor Ben Green argues that cities should be enhanced by technology rather than driven by it, thereby preventing injustice and inequality beneath their surface. By embracing social change in conjunction with smart technologies, residents, Green suggests, can avoid valuing such technologies as ends in themselves.

The Woven City at the base of Mount Fuji in Japan is a ‘living laboratory’ for new technologies. It is being developed by Toyota subsidiary, Woven Planet, and will be the world’s first programmable city.

Companies now make unilateral decisions once reserved for nation-states, such as controlling satellite internet access in active war zones and influencing global information flows. Lawmakers and the international order are struggling to keep up with technological developments, let alone regulate them.

The Space Analog for the Moon and Mars combines the Test Module greenhouse with a workshop, kitchen, common area, sleeping quarters, and a yard that mimics lunar and Martian surfaces. A blind crew member in SAM’s first mission, Inclusion I, helped assess accessibility in potential future space habitats.

The number of startup employees, founders, and investors who have flocked to Silicon Valley over the years makes the California region ideal for networking in the tech space. Plus, California’s laws and specific rules around trade secrets help founders of fledgling businesses in Silicon Valley feel protected.

Many of the philosophies that the leaders of Y Combinator have infused into the program’s portfolio companies have become the playbook for building the next big thing, such as its focus on founder personality and more.