GENOSKIN

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📍 What would  it take to make preclinical safety assessment more predictive of patient outcomes? 📍 👉 At EUROTOX 2026 in Vienna, we presented our poster: “Improving Clinical Translation Through Human Skin-Based New Approach Methodologies” The poster highlights how human ex vivo skin models can help bridge the gap between mechanistic testing and clinical observations by generating human-relevant data earlier in development. Using living human skin tissue, these approaches can support the assessment of: • local tolerability • inflammatory and immune responses • tissue damage • other potential safety liabilities At Genoskin, we develop human ex vivo models and CRO services designed to support more translational toxicology and safety assessment while contributing to efforts to reduce reliance on animal models. 📄 Explore the poster to learn how human skin-based NAMs can strengthen clinical translation and provide deeper insight into human tissue responses: https://lnkd.in/gzPiS-4y #EUROTOX2026 #NAMs #PreclinicalResearch #HumanRelevantResearch #Genoskin

We are growing our Sales team in the US! Please join us in welcoming Lucas Demey, our new Business Development Manager covering the East Coast of the United States. Based in the Boston area, Lucas will support customers across the region, providing a dedicated point of contact for Genoskin’s services and helping research teams identify human-relevant solutions for their nonclinical research needs. Lucas holds a PhD in Microbiology & Molecular Genetics and brings more than a decade of experience in research, spanning molecular biology, cell biology, experimental design and interdisciplinary project management. Most recently, he transitioned into technical sales at VWR, where he supported pharma, biotech and academic customers across the Northeast and developed a strong track record of translating complex scientific needs into practical solutions. At Genoskin, Lucas will work closely with research and commercial teams to understand customer challenges and connect them with our human skin tissue and immune cell platforms. We are delighted to welcome Lucas to the team and look forward to strengthening our support for customers across the US East Coast. Interested in exploring human-relevant platforms for your research? Connect with Lucas or reach out to our team through our contact form: https://bit.ly/4hpYIez

Advancing real-time monitoring in live human tissue A recent publication in Nature Communications demonstrates the potential of a minimally invasive optical probe for real-time, in situ monitoring of metabolites directly within human skin tissue. Using Genoskin’s NativeSkin® ex vivo human skin models, researchers validated the technology’s ability to: 🔹 Monitor ethanol directly in tissue, without extracting interstitial fluid 🔹 Capture rapid concentration changes on sub-minute timescales 🔹 Simultaneously detect ethanol, glucose, and lactate, providing a more comprehensive view of tissue metabolism 🔹 Demonstrate the feasibility of a compact, minimally invasive probe designed for future in vivo monitoring Unlike conventional microdialysis, which relies on fluid extraction and longer sampling intervals, this approach enables high-temporal-resolution measurements while preserving the tissue environment. These findings highlight how human ex vivo skin models can help bridge the gap between innovative sensor technologies and clinical application, providing a relevant platform to validate performance in complex human tissue before moving toward in vivo studies. Congratulations to the Hutter Lab at The University of Texas at Austin. 📖 Read the publication in Nature Communications https://lnkd.in/gqVrSmSN

📣 Webinar alert — the live session is in 2 days! Join Dr Caroline Sokol, from Harvard Medical School and the Ragon Institute of Mass General Brigham, MIT, and Harvard, for a must-attend webinar exploring the emerging science of neuroimmune communication and its potential role in allergic sensitization and disease. This session will offer valuable insights into how the skin detects environmental exposures and why its response may change over time. Recommended for researchers across immunology, allergy, dermatology, neuroscience, and neuroimmune biology. Last chance to secure your place: https://lnkd.in/eSXVTnQJ

👉 Thank you to everyone who stopped by to meet the Genoskin team at EUROTOX 2026 in beautiful Vienna (Austria) ! We truly appreciated the many meaningful conversations around human-relevant toxicology, New Approach Methodologies, and the growing need for more predictive preclinical models. It was a pleasure to exchange perspectives with scientists, toxicologists, and industry experts working to improve how safety and tolerability are assessed before the clinic. 😀 We are grateful for your questions, insights, and interest around our scientific poster presentations. In case you missed them and would like to revisit them, visit our website and download them here. Thank you for making EUROTOX 2026 such a valuable opportunity to connect! #EUROTOX2026 #NAMs #genoskin #exvivohumanskin

What makes a mast cell model truly relevant to human therapeutic development? Mast cells are highly influenced by their tissue environment, anatomical location and surrounding cells — making model selection an important consideration when translating research into therapeutic development. In this new opinion article in BioTechniques, our colleagues Nicolas Gaudenzio, and Chenyan Wu, share their perspectives on: • How mast cell phenotype varies across species, tissues and culture systems • The strengths and limitations of commonly used mast cell models • When human primary cells and tissue-based models add value • Why tissue context matters for understanding therapeutic responses • How to build a fit-for-purpose progression from discovery to translational research The article also explores mast cell depletion strategies and the importance of studying these mechanisms within a relevant human tissue environment. Proud to see the expertise of our scientific team contributing to the broader conversation around human-relevant mast cell research and therapeutic development. 📖 Read the full article in BioTechniques: “Rethinking mast cell research: choosing the right model for human therapeutic development” https://lnkd.in/ehQZB-Y8

We’re grateful for a successful ESDR 2026, filled with insightful discussions, new connections, and inspiring exchanges with the dermatology and skin research communities. Through our participation at ESDR 2026, we highlighted how Genoskin’s human-relevant ex vivo skin models support research into inflammatory responses, immune mechanisms, skin repair, scalp biology, aging, and the biological effects of therapeutic and cosmetic compounds. 🏅 A special highlight of this edition was the recognition of our work on age-associated molecular signatures in human skin, with our Aging poster being selected for a conference prize. We are honored to see this research recognized and to contribute to advancing our understanding of human skin biology. This achievement was made possible by the dedication and expertise of the entire Genoskin team, whose commitment and collaboration allowed us to participate in ESDR 2026 under the best possible conditions and engage in meaningful scientific exchanges. Interested in learning more about our scientific work or accessing the data presented at ESDR 2026? Comment POSTER and we’ll send you access to the scientific work presented at the conference. If you’d like to continue the conversation or learn more about how our human skin models could support your research, feel free to get in touch with our team. #ESDR2026 #Genoskin #exvivohumanskin #NAMs

🧬 EUROTOX 2026 is live in Vienna, Austria. Our team is enjoying insightful discussions with the toxicology community about a shared ambition: advancing safety assessment with more human-relevant science. Thank you to everyone who has visited us so far! It’s been a pleasure to hear about your research challenges, explore potential collaborations, and discuss how ex vivo human skin models can support your next steps. We’re also excited to share our scientific poster, exploring clinical translation through human skin-based New Approach Methodologies (NAMs). 📍 Joining us in Vienna? Stop by booth #51!  Meet the Genoskin team, discover our latest research, and tell us about your projects. We look forward to more great conversations before the conference wraps up! #EUROTOX2026 #Genoskin #Toxicology #NAMs #HumanRelevantResearch

September 14 is World Atopic Eczema Day. For millions of people, atopic eczema is not simply a skin condition. It can affect comfort, sleep, confidence and quality of life, often with an impact that extends well beyond what is visible. Progress starts with better understanding. And better understanding starts with research. At Genoskin, we support scientists working to advance atopic eczema research by providing human skin models designed to generate more relevant insights into disease mechanisms and potential treatments. Our goal is to help researchers go further, from understanding the biology of the disease to exploring new therapeutic approaches. On World Atopic Eczema Day, we stand alongside patients, families, healthcare professionals and researchers working toward better solutions for people living with atopic eczema. Supporting research today can help shape better care tomorrow. #WorldAtopicEczemaDay #SkinResearch #HumanSkinModels