Innophore

I'm excited to share our recent publication on nature.com: 🧪🔬🚀 “Data-driven construction of an imine reductase library capable of broad-scope reductive amination at equimolar substrate concentrations.” Proud to be first co-author together with Sarah Berger and grateful to be part of the Uni Graz project with amazing collaborators at Roche and Innophore. Along the way, I enjoyed fantastic discussions, teamwork, and outstanding coordination by my former supervisor Jörg Schrittwieser! 🤝💡 In short: We present a data-driven approach to assemble an IRED library that enables broad-scope reductive amination at 1:1 substrate ratios, advancing efficient, selective, and more sustainable biocatalysis. 🌱 Check out our prediction of the IREDs' enantioselectivity with three key amino acid residues! 🌟 Read more: https://lnkd.in/eEvfAWjK #UniGraz #Roche #Innophore #Biocatalysis #ImineReductase #ReductiveAmination #DataDriven #EnzymeEngineering #GreenChemistry #TeamScience A huge thanks to all collaborators: Sarah Berger, Marco Cespugli, Andreas Krassnigg, Tobias Schopper, Isabel Oroz Guinea, Stephan Vrabl, Lukas Römer, Melanie Weber, Fabian Kulier, Yuliya Orel, Bettina Nestl, Christian C. Gruber, Georg Steinkellner, Serena Bisagni, Francis Gosselin, Hans Iding, Kurt Püntener, Dennis Wetzl, Wolfgang Kroutil & Jörg Schritwieser

Our free PyMOL plugin has 73+ recent mentions in the scientific literature - here's where CavitOmiX shows up. 🧬 When we released CavitOmiX, the idea was simple: make our Catalophore™ point-cloud cavity technology available to anyone working on protein pockets, straight inside PyMOL, for free. We went back to the literature to see how researchers are actually using it. The result: 73+ publications reference CavitOmiX, Catalophore or DrugSolver, and in 38 studies we could confirm hands-on use directly in the methods. What stands out is the range of science it supports: 🔹 GPCRs — mapping the internal cavity and bottleneck of Frizzled-7 (Nature Communications) 🔹 Enzymes — resolving substrate and cofactor funnels, active sites and reaction mechanisms 🔹 Drug repurposing & antivirals — screening binding-site point clouds against approved drugs 🔹 Transporters, natural products, and even crop protection — from lipid-binding cavities to acaricide resistance in spider mites Adoption is also accelerating: 4 studies in 2023 → 9 in 2024 → 16 in 2025. Some examples in the carousel below: Swipe through to see the cavity science in action. 👉 Want to find your cavities? The plugin is free; get it here: https://lnkd.in/dzZYM5NZ #CavitOmiX #Innophore #DrugDiscovery #StructuralBiology #ComputationalChemistry #PyMOL #Bioinformatics #ProteinScience #GPCR #Enzymology #AI

Every protein discovery starts with the same question: "Is there something out there that does what we need - and we just can't see it yet?" Most tools compare proteins by what they look like. We at Innophore compare them by what they do - at the binding-site level, in 3D, at scale. The result? Functional matches no one thought to look for. Enzymes hidden in plain sight. No black box. Just protein chemistry, cavities, physics and AI - with our experienced scientists in the loop. 📄 See the infographic for how it works. Over the coming weeks, I'll be reaching out personally to explore how we can build a tailored use case together - combining our technology and deep domain expertise with your discovery goals. In the meantime: curious whether your target is a fit? Let's talk. 🔗 www.innophore.com #ProteinDiscovery #EnzymeEngineering #DrugDiscovery #AI #Biotech #Innophore

Every protein discovery starts with the same question: "Is there something out there that does what we need - and we just can't see it yet?" Most tools compare proteins by what they look like. We at Innophore compare them by what they do - at the binding-site level, in 3D, at scale. The result? Functional matches no one thought to look for. Enzymes hidden in plain sight. No black box. Just protein chemistry, cavities, physics and AI - with our experienced scientists in the loop. 📄 See the infographic for how it works. Over the coming weeks, I'll be reaching out personally to explore how we can build a tailored use case together - combining our technology and deep domain expertise with your discovery goals. In the meantime: curious whether your target is a fit? Let's talk. 🔗 www.innophore.com #ProteinDiscovery #EnzymeEngineering #DrugDiscovery #AI #Biotech #Innophore

We're at bio:cap 2026! Meet us at the Life Science & AI Investival, June 9–11, at CityCube Messe Berlin. Christian C. Gruber and Lena Parigger are looking forward to connecting with pharma and biotech partners working in enzyme and drug discovery, engineering and virtual screening. Whether you're exploring software licensing, research collaborations, or strategic partnerships - let's talk! Come meet us at our booth: Hall B | 1b #biocap2026 #AIDrugDiscovery #Biotech #EnzymeEngineering #Biocatalysis #Innovation

Last week, our colleague Lena Parigger was invited to speak at WiDS Villach 2026! WiDS Worldwide (Women in Data Science) brings together inspiring voices to make STEM fields more inclusive and accessible. Lena shared insights on her work and the role of advanced computational methods in drug discovery. This invitation follows Lena's recent recognition with the Frauenförderpreis für Digitalisierung und Innovation (Women's Advancement Award for Digitalization and Innovation, sponsored by Infineon Technologies Austria and ORF), and reflects her growing involvement in initiatives that encourage young women to pursue careers in science and technology. We're grateful to WiDS Villach and all the organizations making events like this possible. Building a diverse, inclusive tech community benefits everyone - from better research outcomes to more innovative problem-solving. Thank you to the organizers and all sponsors and partners who made this event happen. Looking forward to WiDS 2027! Check out Lena's work: https://lnkd.in/dFJXQHw8 📸 WiDS Villach 2026 / Monika Aigner #WiDSVillach #WiDS2026 #WomenInDataScience #DataScience #Innovation #STEM #DrugDiscovery

🎉 Proud moment for the Innophore team! Tobias Schopper and Michael Hetmann represented us at the #AIRoV 2026 in Leoben last week - with beautiful posters explaining our LigForge Module - Physics-informed Diffusion and #CavitOmiX - off target prediction in the proteom. Congratulations! Michael also took the stage with a dedicated talk - a great opportunity to bring #Innophore's approach to protein function prediction and cavity analysis into the broader research conversation. Excited to see how these connections evolve!

🚀 Enzyme Discovery Just Got Faster & Easier! 🚀 We are excited to announce that Innophore is updated on Scientist.com and ScienceExchange.com ! 🧬✨ By bringing our Catalophore™ platform to this R&D marketplace, we’re making it simpler than ever for biotech and pharma teams to access world-class enzyme discovery and protein engineering. Why work with us via Science Exchange or Scientist? ✅ Fast-Track Procurement: Skip the lengthy legal and administrative hurdles with pre-signed Master Service Agreements (MSAs). ✅ Seamless Collaboration: Manage your entire project, from quote to final report, in one centralized, secure dashboard. ✅ Trusted Compliance: Benefit from Science Exchange’s rigorous SOC2-certified infrastructure and simplified payment processing. Stop searching and start discovering. Access Innophore’s expertise today and accelerate your path to the perfect biocatalyst. #Biotech #EnzymeDiscovery  #Innophore #ProteinEngineering #Biocatalysis #Bioinformatics #Pharma #Copilot #InhibitorSearch #Stability