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How to get fromPort Saint Lucie to Louisvilleby bus, plane, bus (Flixbus, Greyhound, Amtrak), car, taxi, or bus (Greyhound, Amtrak)

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There are 9 ways to get from Port Saint Lucie to Louisville by bus, plane, bus (Flixbus, Greyhound, Amtrak), car, taxi, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Orlando, fly to Louisville International Airport

    best
    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to Louisville International Airport (SDF)plane plane MCO - SDF
    7h 37m
    $425–846

  2. Drive to Orlando Sanford, fly to Blue Grass Airport, drive

    cheapest
    1. Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Blue Grass Airport (LEX)plane plane SFB - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 46m
    $107–444

  3. Bus

    1. Take the bus from Port St Lucie to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    20h 15m
    $176–281

  4. Drive  927.1 mi

    1. Drive from Port Saint Lucie to Louisvillecar car 927.1 mi
    16h 29m
    $170–245

  5. Bus to Fort Lauderdale–Hollywood International Airport, fly to Louisville International Airport

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Louisville International Airport (SDF)plane plane FLL - SDF
    7h 10m
    $182–896

  6. Bus to Miami International Airport, fly to Louisville International Airport

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Miami International Airport (MIA) to Louisville International Airport (SDF)plane plane MIA - SDF
    7h 43m
    $164–747

  7. Bus to Tampa, fly to Louisville International Airport

    1. Take the bus from Port St Lucie to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Louisville International Airport (SDF)plane plane TPA - SDF
    9h 48m
    $184–792

  8. Bus, taxi to Melbourne International Airport, fly to Louisville International Airport

    1. Take the bus from Fort Pierce to Sebastianbus bus
    2. Take the taxi from Sebastian to Melbourne International Airport (MLB)taxi taxi
    3. Fly from Melbourne International Airport (MLB) to Louisville International Airport (SDF)plane plane MLB - SDF
    10h 53m
    $221–821

  9. Bus via Tallahassee

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Tallahassee - FSU - Old St Augustine at Intramural Fieldbus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Nashville to Louisville, KYbus bus
    24h 44m
    $207–316

Orlando (MCO) to Louisville International Airport (SDF) flights

Calendar50Weekly Planes
Duration2h 33mAverage Duration
Ticket$121Cheapest Price
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Comparing Your Travel Options

Map of how to get from Port Saint Lucie to Louisville.ExpandLaunch map view
  • Distance: 862 mi
  • Duration: 7h 37m

What companies run services between Port Saint Lucie, FL, USA and Louisville, KY, USA?

You can take a vehicle from Port Saint Lucie to Louisville, KY via Port St Lucie, Atlanta Bus Station, and Nashville in around 20h 15m.

Airlines
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Other operators

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