There are 6 ways to get from Syracuse to Brookville by bus (Flixbus, Greyhound), train, bus, car, plane, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Syracuse to Buffalobus Adt N804 / ...
- Take the bus from Buffalo to Sykesvillebus Fab530
9h 48m$104–251Drive 255.7 mi
cheapest- Drive from Syracuse to Brookvillecar 255.7 mi
5h 36m$47–68Train, bus
- Take the train from Syracuse Regional Transportation Center to Cleveland Amtraktrain Lake Shore Limited
- Take the bus from Cleveland, OH to Exit 62 BP - Clarion, PAbus Cleveland-New York
10h 15m$283–382Fly to Penn State University Park Airport, bus
- Fly from Syracuse Hancock International Airport (SYR) to Penn State University Park Airport (SCE)plane SYR - SCE
- Take the bus from State College to DuBoisbus
8h 34m$105–567Bus via Buffalo Airport (BUF)
- Take the bus from Syracuse Bus Station to Buffalo Niagara International Airportbus FlixBus 2686 / ...
- Take the bus from Buffalo to Sykesvillebus Fab530
10h 29m$109–301Fly to Du Bois-Jefferson County Airport
- Fly from Syracuse Hancock International Airport (SYR) to Du Bois-Jefferson County Airport (DUJ)plane SYR - DUJ
5h 46m$95–562
Syracuse Hancock International Airport (SYR) to Penn State University Park Airport (SCE) flights
Comparing Your Travel Options
The cheapest way to get from Syracuse to Brookville is to drive which costs $45 - $70 and takes 5h 36m.
The fastest way to get from Syracuse to Brookville is to drive which takes 5h 36m and costs $45 - $70.
No, there is no direct bus from Syracuse to Brookville. However, there are services departing from Syracuse and arriving at Sykesville via Buffalo. The journey, including transfers, takes approximately 9h 48m.
The distance between Syracuse and Brookville is 376 miles. The road distance is 257.2 miles.
The best way to get from Syracuse to Brookville without a car is to bus which takes 9h 48m and costs $100 - $260.
It takes approximately 9h 48m to get from Syracuse to Brookville, including transfers.
Syracuse to Brookville bus services, operated by Trailways, depart from Syracuse station.
The best way to get from Syracuse to Brookville is to bus which takes 9h 48m and costs $100 - $260. Alternatively, you can fly, which costs $95 - $600 and takes 5h 46m.
Syracuse to Brookville bus services, operated by Trailways, arrive at Buffalo station.
Yes, the driving distance between Syracuse to Brookville is 257 miles. It takes approximately 5h 36m to drive from Syracuse to Brookville.
What companies run services between Syracuse, NY, USA and Brookville, PA, USA?
You can take a bus from Syracuse to Brookville via Buffalo and Sykesville in around 9h 48m. Alternatively, United Airlines, Southern Airways Express, and American Airlines fly from Syracuse Hancock International Airport (SYR) to Du Bois-Jefferson County Airport (DUJ) 5 times a day.
- Website
- iflysouthern.com
Flights from Syracuse Hancock International Airport to Du Bois-Jefferson County Airport via Washington Dulles
- Ave. Duration
- 3h 53m
- When
- Every day
- Estimated price
- $85–550
Flights from Syracuse Hancock International Airport to Du Bois-Jefferson County Airport via Philadelphia, Pittsburgh
- Ave. Duration
- 6h 51m
- When
- Every day
- Estimated price
- $95–550
Flights from Syracuse Hancock International Airport to Du Bois-Jefferson County Airport via Washington Dulles, Pittsburgh
- Ave. Duration
- 6h 48m
- When
- Every day
- Estimated price
- $95–550
- Website
- united.com
Flights from Syracuse Hancock International Airport to Penn State University Park Airport via Washington Dulles
- Ave. Duration
- 3h 49m
- When
- Every day
- Estimated price
- $80–550
Flights from Syracuse Hancock International Airport to Penn State University Park Airport via Chicago O'Hare
- Ave. Duration
- 7h 7m
- When
- Monday to Saturday
- Estimated price
- $140–750
- Website
- aa.com
Flights from Syracuse Hancock International Airport to Penn State University Park Airport via Philadelphia
- Ave. Duration
- 4h 23m
- When
- Every day
- Estimated price
- $80–500
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Syracuse Regional Transportation Center to Cleveland Amtrak
- Ave. Duration
- 5h 48m
- Frequency
- Twice daily
- Estimated price
- $180–280
- Website
- Amtrak
- Phone
- +1 800-858-8555
- Website
- Trailways
Bus from Syracuse to Buffalo
- Ave. Duration
- 3h 10m
- Frequency
- 5 times a day
- Estimated price
- $28–100
- Website
- Trailways
- Schedules at
- Trailways
- Saver
- $28–95
- Flexible
- $55–100
Bus from Syracuse Bus Station to Buffalo Niagara International Airport
- Saver
- $27–85
- Flexible
- $50–90
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Syracuse to Buffalo
- Ave. Duration
- 3h 5m
- Frequency
- 5 times a day
- Estimated price
- $24–40
- Schedules at
- Flixbus USA
Bus from Syracuse Bus Station to Buffalo Niagara International Airport
- Ave. Duration
- 2h 45m
- Frequency
- 5 times a day
- Estimated price
- $22–35
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Syracuse to Buffalo
- Ave. Duration
- 3h
- Frequency
- 5 times a day
- Estimated price
- $26–45
- Website
- Greyhound
- Phone
- +1 814-574-1827
- Website
- Fullington Tours
Bus from Buffalo to Sykesville
- Ave. Duration
- 5h 10m
- Frequency
- Once daily
- Estimated price
- $45–160
- Website
- Fullington Tours
Bus from State College to DuBois
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $15–55
- Website
- Fullington Tours
Bus from Buffalo to Sykesville
- Ave. Duration
- 5h 10m
- Frequency
- Once daily
- Estimated price
- $45–160
- Website
- Fullington Tours
Bus from Cleveland, OH to Exit 62 BP - Clarion, PA
- Ave. Duration
- 2h 20m
- Frequency
- 5 times a week
- Estimated price
- $90
- Schedules at
- Great Wall Bus
- Passenger
- $90
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There are 16+ hotels available in Brookville.