There are 5 ways to get from Santa Cruz to Santiago by bus (Flixbus), bus, train, car, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Hospital to Terminal Sur de Santiagobus Santiago
2h 42m$4–35Bus, train
cheapest- Take the bus from Hospital to Terminal Rodoviario de San Fernandobus Santiago
- Take the train from San Fernando to Estacion Central Alamedatrain San Fernando / ...
3h 45m$2–10Drive 180 km
- Drive from Santa Cruz to Santiagocar 180 km
2h 4m$23–33Taxi
- Take the taxi from Santa Cruz to Santiagotaxi 180 km
2h 4m$130–160Bus via Santiago (Flixbus)
- Take the bus from Santa Cruz to Santiagobus FlixBus CL027
2h 49m$16–58
Santa Cruz to Santiago by bus
Comparing Your Travel Options
The cheapest way to get from Santa Cruz to Santiago is to bus and train which costs $1 - $10 and takes 3h 45m.
The fastest way to get from Santa Cruz to Santiago is to drive which takes 2h 4m and costs $22 - $35.
Yes, there is a direct bus departing from Hospital and arriving at Terminal Sur de Santiago. Services depart every two hours, and operate every day. The journey takes approximately 2h 42m.
The distance between Santa Cruz and Santiago is 218 km. The road distance is 180 km.
The best way to get from Santa Cruz to Santiago without a car is to bus which takes 2h 42m and costs $4 - $35.
The bus from Hospital to Terminal Sur de Santiago takes 2h 42m including transfers and departs every two hours.
Santa Cruz to Santiago bus services, operated by Andimar, depart from Hospital station.
Santa Cruz to Santiago bus services, operated by Andimar, arrive at Terminal Sur de Santiago station.
Yes, the driving distance between Santa Cruz to Santiago is 180 km. It takes approximately 2h 4m to drive from Santa Cruz to Santiago.
Book your Santa Cruz to Santiago bus tickets online with Omio and FlixBus.
What companies run services between Santa Cruz, O'Higgins, Chile and Santiago, Chile?
Andimar operates a bus from Hospital to Terminal Sur de Santiago hourly. Tickets cost $4–12 and the journey takes 2h 42m. Five other operators also service this route.
- Phone
- +56 22 585 5000
- contacto@trencentral.cl
- Website
- efe.cl
Train from San Fernando to Estacion Central Alameda
- Phone
- +56 22 683 8528
- hola@andimar.cl
- Website
- Andimar
Bus from Hospital to Terminal Sur de Santiago
- Ave. Duration
- 2h 42m
- Frequency
- Hourly
- Estimated price
- $4–12
- Schedules at
- Andimar
- Semi Cama
- $4–9
- Cama
- $6–12
Bus from Hospital to Terminal Rodoviario de San Fernando
- Ave. Duration
- 52 min
- Frequency
- Hourly
- Estimated price
- $1–5
- Schedules at
- Andimar
- Semi Cama
- $1–5
- Cama
- $1–4
- ayuda@kupos.com
- Website
- Expreso Santa Cruz
Bus from Hospital to Terminal Sur de Santiago
- Ave. Duration
- 3h
- Frequency
- Every 30 minutes
- Estimated price
- $7
- Schedules at
- Expreso Santa Cruz
- Phone
- +56 2 2479 2925 / 2 2479 9879 / 9 6190 6054
- servicioalcliente@transantin.cl
- Website
- TranSantin
Bus from Hospital to Terminal Sur de Santiago
- Ave. Duration
- 3h 20m
- Frequency
- Every 30 minutes
- Estimated price
- $5–11
- Schedules at
- TranSantin
- Road
- $5–11
- Website
- Flixbus Chile
Bus from Hospital to Terminal Sur de Santiago
- Ave. Duration
- 2h 44m
- Frequency
- Every 2 hours
- Estimated price
- $20–30
- Schedules at
- Flixbus Chile
Bus from Santa Cruz to Santiago
- Ave. Duration
- 2h 24m
- Frequency
- Every 2 hours
- Estimated price
- $15–24
- Schedules at
- Flixbus Chile
- Phone
- +56 600 600 0018
- clientes@pullmanbus.cl
- Website
- pullmanbus.cl
Bus from Hospital to Terminal Sur de Santiago
- Ave. Duration
- 3h
- Frequency
- 4 times a day
- Estimated price
- $11–35
- Schedules at
- pullmanbus.cl
- Book at
- pullmanbus.cl
- Salón Cama
- $14–35
- Phone
- +56 2 2666 5505
- ayuda@recorrido.cl
- Website
- Buses Jetsur
Bus from Hospital to Terminal Sur de Santiago
- Ave. Duration
- 3h 13m
- Frequency
- 4 times a day
- Estimated price
- $10–12
- Website
- Buses Jetsur
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Booking & Getting There
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