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How to get fromSan Luis Obispo to Mesaby plane, tram, bus (Flixbus, Greyhound), train, bus, car, or taxi

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There are 8 ways to get from San Luis Obispo to Mesa by plane, tram, bus (Flixbus, Greyhound), train, bus, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from San Luis Obispo County Regional Airport, tram

    best
    1. Fly from San Luis Obispo County Regional Airport (SBP) to Phoenix (PHX)plane plane SBP - PHX
    2. Take the tram from 44th St/Washington to Mesa Dr/Main Sttram tram
    3h 59m
    $132–254

  2. Bus

    cheapest
    1. Take the bus from San Luis Obispo Railroad Museum to Los Angeles Union Stationbus bus FlixBus 2005
    2. Take the bus from Los Angeles Union Station to Phoenix Bus Stationbus bus Greyhound US1000 / ...
    13h 41m
    $85–139

  3. Train, bus

    1. Take the train from San Luis Obispo to Los Angelestrain train Pacific Surfliner / ...
    2. Take the bus from Los Angeles to Phoenixbus bus Lxus 2224 / ...
    14h 32m
    $182–272

  4. Drive  571.9 mi

    1. Drive from San Luis Obispo to Mesacar car 571.9 mi
    9h 42m
    $105–151

  5. Bus to Santa Barbara Municipal Airport, fly

    1. Take the bus from San Luis Obispo to Uc Santa Barbara Amtrak Bus Stopbus bus
    2. Fly from Santa Barbara Municipal Airport (SBA) to Phoenix (PHX)plane plane SBA - PHX
    6h 5m

  6. Train, taxi (Amtrak)

    1. Take the train from San Luis Obispo to Los Angelestrain train
    2. Take the train from Los Angeles to Maricopa Amtraktrain train
    3. Take the taxi from Maricopa Amtrak to Mesataxi taxi
    14h 57m
    $428–658

  7. Train, bus via Van Nuys

    1. Take the train from San Luis Obispo to Van Nuystrain train Pacific Surfliner / ...
    2. Take the bus from Los Angeles - Pacoima to Phoenixbus bus San Jose
    17h 28m
    $164–250

  8. Train, bus #2

    1. Take the train from San Luis Obispo to Santa Anatrain train Pacific Surfliner
    2. Take the bus from Santa Ana to Phoenixbus bus Cbx
    18h 16m
    $209–314

San Luis Obispo to Mesa by bus

Calendar4Weekly Buses
Duration13h 41mAverage Duration
Ticket$85Cheapest Price
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Comparing Your Travel Options

Map of how to get from San Luis Obispo to Mesa.ExpandLaunch map view
  • Distance: 526.7 mi
  • Duration: 3h 59m

What companies run services between San Luis Obispo, CA, USA and Mesa, AZ, USA?

You can take a bus from San Luis Obispo Railroad Museum to University Dr & Mesa Dr via Los Angeles Union Station, Phoenix, Bus Station (E Buckeye Rd), 24th St & Buckeye Rd, and 24th St/Baseline PNR in around 13h 41m.

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