There are 7 ways to get from San Diego to Winston-Salem by plane, bus (Flixbus, Greyhound), bus, train, car, or train (Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Piedmont Triad International Airport
best- Fly from San Diego International Airport (SAN) to Piedmont Triad International Airport (GSO)plane SAN - GSO
7h 35m$261–1,039Fly to Charlotte Douglas International Airport, bus
cheapest- Fly from San Diego International Airport (SAN) to Charlotte Douglas International Airport (CLT)plane SAN - CLT
- Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus
7h 44m$142–334Bus
- Take the bus from San Diego to Los Angeles Union Stationbus
- Take the bus from Los Angeles Union Station to Dallas Bus Stationbus
- Take the bus from Dallas Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus
2d 11h$464–713Bus, train
- Take the bus from San Diego to Fullerton Amtrak Stationbus
- Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain
- Take the bus from Chicago to Columbusbus
- Take the bus from Columbus to Winston Salem(Trans Center)bus
2d 17hDrive 2,396.3 mi
- Drive from San Diego to Winston-Salemcar 2,396.3 mi
39h 22m$438–632Fly to Raleigh-Durham International Airport, bus
- Fly from San Diego International Airport (SAN) to Raleigh-Durham International Airport (RDU)plane SAN - RDU
- Take the bus from Durham to Winston Salem(Trans Center)bus
9h 10m$169–648Train (Amtrak)
- Take the train from San Diego to Los Angelestrain
- Take the train from Los Angeles to New Orleans Union Passenger Terminaltrain
- Take the train from New Orleans Union Passenger Terminal to High Pointtrain
3d 1h$1,643–2,564
San Diego to Winston-Salem by bus
Comparing Your Travel Options
The cheapest way to get from San Diego to Winston-Salem is to fly and bus which costs $140 - $340 and takes 7h 44m.
The fastest way to get from San Diego to Winston-Salem is to fly which takes 7h 35m and costs $260 - $1,100.
No, there is no direct bus from San Diego to Winston-Salem. However, there are services departing from San Diego and arriving at Winston Salem(Trans Center) via Los Angeles Union Station, Dallas Bus Station and Atlanta Bus Station. The journey, including transfers, takes approximately 2 days 11h.
No, there is no direct train from San Diego to Winston-Salem. However, there are services departing from San Diego and arriving at High Point via Los Angeles and New Orleans Union Passenger Terminal. The journey, including transfers, takes approximately 3 days 1h.
The distance between San Diego and Winston-Salem is 2159 miles. The road distance is 2410.3 miles.
The best way to get from San Diego to Winston-Salem without a car is to bus which takes 2 days 11h and costs $460 - $750.
It takes approximately 7h 35m to get from San Diego to Winston-Salem, including transfers.
San Diego to Winston-Salem bus services, operated by Flixbus USA, depart from San Diego station.
San Diego to Winston-Salem train services, operated by Amtrak, depart from San Diego station.
The best way to get from San Diego to Winston-Salem is to fly which takes 7h 35m and costs $260 - $1,100. Alternatively, you can bus, which costs $460 - $750 and takes 2 days 11h, you could also train, which costs $1,600 - $2,600 and takes 3 days 1h.
What companies run services between San Diego, CA, USA and Winston-Salem, NC, USA?
Delta, American Airlines, and United Airlines fly from San Diego International Airport (SAN) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from San Diego to Winston Salem(Trans Center) via Los Angeles Union Station, Dallas Bus Station, and Atlanta Bus Station in around 2d 11h.
- Website
- delta.com
Flights from San Diego International Airport to Piedmont Triad International Airport via Atlanta
- Ave. Duration
- 6h 57m
- When
- Every day
- Estimated price
- $240–1,100
Flights from San Diego International Airport to Piedmont Triad International Airport via Detroit
- Ave. Duration
- 7h 53m
- When
- Every day
- Estimated price
- $260–1,100
Flights from San Diego International Airport to Charlotte Douglas International Airport via Atlanta
- Ave. Duration
- 7h 25m
- When
- Every day
- Estimated price
- $160–750
Flights from San Diego International Airport to Raleigh-Durham International Airport via Atlanta
- Ave. Duration
- 7h 22m
- When
- Every day
- Estimated price
- $150–650
- Website
- aa.com
Flights from San Diego International Airport to Piedmont Triad International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 7h 33m
- When
- Every day
- Estimated price
- $240–1,100
Flights from San Diego International Airport to Piedmont Triad International Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 9m
- When
- Every day
- Estimated price
- $240–1,100
Flights from San Diego International Airport to Piedmont Triad International Airport via Chicago O'Hare
- Ave. Duration
- 9h 2m
- When
- Every day
- Estimated price
- $250–1,100
Flights from San Diego International Airport to Charlotte Douglas International Airport
- Ave. Duration
- 4h 42m
- When
- Every day
- Estimated price
- $160–700
- Website
- southwest.com
Flights from San Diego International Airport to Charlotte Douglas International Airport via Nashville
- Ave. Duration
- 6h 51m
- When
- Tuesday, Wednesday, and Sunday
- Estimated price
- $160–700
Flights from San Diego International Airport to Charlotte Douglas International Airport via Dallas
- Ave. Duration
- 7h 2m
- When
- Saturday, Monday, Thursday, and Friday
- Estimated price
- $160–750
Flights from San Diego International Airport to Raleigh-Durham International Airport via Nashville
- Ave. Duration
- 7h 10m
- When
- Tuesday, Wednesday, Thursday, and Sunday
- Estimated price
- $140–650
Flights from San Diego International Airport to Raleigh-Durham International Airport via St. Louis
- Ave. Duration
- 6h 55m
- When
- Saturday
- Estimated price
- $150–650
- Website
- united.com
Flights from San Diego International Airport to Piedmont Triad International Airport via Chicago O'Hare
- Ave. Duration
- 7h 50m
- When
- Every day
- Estimated price
- $250–1,100
Flights from San Diego International Airport to Piedmont Triad International Airport via Washington Dulles
- Ave. Duration
- 7h 45m
- When
- Saturday and Friday
- Estimated price
- $270–1,200
- Website
- alaskaair.com
Flights from San Diego International Airport to Charlotte Douglas International Airport
- Ave. Duration
- 4h 42m
- When
- Every day
- Estimated price
- $160–700
Flights from San Diego International Airport to Raleigh-Durham International Airport
- Ave. Duration
- 4h 58m
- When
- Every day
- Estimated price
- $210–900
- Website
- flybreeze.com
Flights from San Diego International Airport to Raleigh-Durham International Airport
- Ave. Duration
- 4h 55m
- When
- Thursday, Sunday, and Tuesday
- Estimated price
- $210–1,100
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Fullerton Amtrak Station to Chicago Union Station
- Ave. Duration
- 42h 47m
- Frequency
- Once daily
- Estimated price
- $1,200–1,900
- Website
- Amtrak
Train from San Diego to Los Angeles
- Ave. Duration
- 2h 56m
- Frequency
- Hourly
- Estimated price
- $70–110
- Website
- Amtrak
Train from Los Angeles to New Orleans Union Passenger Terminal
- Ave. Duration
- 45h 40m
- Frequency
- 3 times a week
- Estimated price
- $1,100–1,700
- Website
- Amtrak
Train from New Orleans Union Passenger Terminal to High Point
- Ave. Duration
- 20h 51m
- Frequency
- Once daily
- Estimated price
- $470–750
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from San Diego to Los Angeles Union Station
- Ave. Duration
- 2h 35m
- Frequency
- Twice daily
- Estimated price
- $19–29
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Los Angeles Union Station to Dallas Bus Station
- Ave. Duration
- 29h 5m
- Frequency
- Twice daily
- Estimated price
- $250–380
- Website
- Greyhound
Bus from Dallas Bus Station to Atlanta Bus Station
- Ave. Duration
- 18h 5m
- Frequency
- 3 times a day
- Estimated price
- $140–220
- Website
- Greyhound
Bus from Atlanta Bus Station to Winston Salem(Trans Center)
- Ave. Duration
- 6h 20m
- Frequency
- Twice daily
- Estimated price
- $55–85
- Website
- Greyhound
Bus from Columbus to Winston Salem(Trans Center)
- Ave. Duration
- 9h 20m
- Frequency
- Once daily
- Estimated price
- $70–110
- Website
- Greyhound
Bus from Charlotte Bus Station to Winston Salem(Trans Center)
- Ave. Duration
- 1h 25m
- Frequency
- Twice daily
- Estimated price
- $13–20
- Website
- Greyhound
Bus from Durham to Winston Salem(Trans Center)
- Ave. Duration
- 1h 45m
- Frequency
- 3 times a day
- Estimated price
- $14–21
- Website
- Greyhound
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from San Diego to Fullerton Amtrak Station
- Ave. Duration
- 2h 40m
- Frequency
- Once daily
- Website
- Amtrak
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- Barons Bus
Bus from Chicago to Columbus
- Ave. Duration
- 7h 50m
- Frequency
- Twice daily
- Estimated price
- $30–80
- Website
- Barons Bus
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guideNeed to know: Greyhound
Read the travel guideWhy you should take the train in the US
Read the travel guideBooking & Getting There
San Diego to Winston-Salem bus services, operated by Flixbus USA, arrive at Los Angeles Union Station.
Winston-Salem is 3h ahead of San Diego. It is currently 00:03 in San Diego and 03:03 in Winston-Salem.
San Diego to Winston-Salem train services, operated by Amtrak, arrive at Los Angeles station.
Yes, the driving distance between San Diego to Winston-Salem is 2410 miles. It takes approximately 39h 22m to drive from San Diego to Winston-Salem.
Book your San Diego to Winston-Salem train tickets online with Omio.
Book your San Diego to Winston-Salem bus tickets online with Omio and FlixBus.
There are 151+ hotels available in Winston-Salem.