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How to get fromMayo Clinic to West Des Moinesby bus (Greyhound), car, plane, or bus

Find Transport to West Des Moines

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There are 5 ways to get from Mayo Clinic to West Des Moines by bus (Greyhound), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Rochester to St. Paulbus bus Jefferson Lines 966
    2. Take the bus from Saint Paul Union Depot to Des Moinesbus bus Greyhound US0156
    7h 23m
    $91–131

  2. Drive  213.7 mi

    cheapest
    1. Drive from Mayo Clinic to West Des Moinescar car 213.7 mi
    3h 36m
    $39–57

  3. Fly from Rochester

    1. Fly from Rochester (RST) to Des Moines (DSM)plane plane RST - DSM
    4h 36m
    $64–380

  4. Bus via Minneapolis Airport (MSP)

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus Groome Transportation
    2. Take the bus from Saint Paul Union Depot to Des Moinesbus bus Greyhound US0156
    7h 52m
    $114–145

  5. Bus to Minneapolis–Saint Paul International Airport, fly

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Des Moines (DSM)plane plane MSP - DSM
    3h 52m
    $123–453

Rochester (RST) to Des Moines (DSM) flights

Calendar35Weekly Planes
Duration4h 49mAverage Duration
Ticket$49Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mayo Clinic to West Des Moines.ExpandLaunch map view
  • Distance: 331.9 mi
  • Duration: 7h 23m

What companies run services between Mayo Clinic, MN, USA and West Des Moines, IA, USA?

You can take a vehicle from Mayo Clinic to West Des Moines via Rochester, Saint Paul Union Depot, and Des Moines in around 7h 23m. Alternatively, Delta and American Airlines fly from Rochester (RST) to Des Moines (DSM) 5 times a day.

Airlines
Bus operators

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