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How to get fromMayo Clinic to Hilton Head Islandby plane, taxi, bus, train, or car

Find Transport to Hilton Head Island

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There are 7 ways to get from Mayo Clinic to Hilton Head Island by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Savannah, taxi

    best
    1. Fly from Rochester (RST) to Savannah (SAV)plane plane RST - SAV
    2. Take the taxi from Savannah (SAV) to Hilton Head Islandtaxi taxi
    7h 24m
    $301–977

  2. Bus to Minneapolis–Saint Paul International Airport, fly to Hilton Head Airport

    cheapest
    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Hilton Head Airport (HHH)plane plane MSP - HHH
    8h 56m
    $228–622

  3. Bus, train, taxi via Atlanta

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus
    5. Take the train from Charleston Amtrak Station to Savannah Stationtrain train
    6. Take the taxi from Savannah Station to Hilton Head Islandtaxi taxi
    41h 38m
    $463–709

  4. Bus, train, taxi

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Savannah Stationtrain train
    4. Take the taxi from Savannah Station to Hilton Head Islandtaxi taxi
    42h 35m
    $980–1,524

  5. Drive  1,261.5 mi

    1. Drive from Mayo Clinic to Hilton Head Islandcar car 1,261.5 mi
    22h 33m
    $231–333

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Savannah, taxi

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Savannah (SAV)plane plane MSP - SAV
    3. Take the taxi from Savannah (SAV) to Hilton Head Islandtaxi taxi
    6h 6m
    $390–1,190

  7. Bus, train, taxi #2

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Savannah Stationtrain train
    4. Take the taxi from Savannah Station to Hilton Head Islandtaxi taxi
    43h 46m
    $1,149–1,779

Rochester (RST) to Savannah (SAV) flights

Calendar35Weekly Planes
Duration6h 53mAverage Duration
Ticket$150Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mayo Clinic to Hilton Head Island.ExpandLaunch map view
  • Distance: 1,064.1 mi
  • Duration: 7h 24m

What companies run services between Mayo Clinic, MN, USA and Hilton Head Island, SC, USA?

There is no direct connection from Mayo Clinic to Hilton Head Island. However, you can walk to Rochester, take the bus to Rochester, walk to Rochester (RST) airport, fly to Savannah (SAV), then take the taxi to Hilton Head Island. Alternatively, you can walk to Rochester, take the bus to Milwaukee, walk to Milwaukee Intermodal Station, take the bus to Chicago Bus Station, take the bus to Atlanta Bus Station, take the bus to Charleston Bus Station, walk to Charleston Amtrak Station, take the train to Savannah Station, then take the taxi to Hilton Head Island.

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