There are 5 ways to get from Mayo Clinic to Grafton by bus, car, plane, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Rochester to Milwaukeebus Jefferson Lines 965
7h 9m$99–135Drive 255.3 mi
cheapest- Drive from Mayo Clinic to Graftoncar 255.3 mi
4h 59m$47–68Fly Rochester to General Mitchell International Airport
- Fly from Rochester (RST) to General Mitchell International Airport (MKE)plane RST - MKE
6h 15m$104–545Bus to Minneapolis–Saint Paul International Airport, fly to General Mitchell International Airport, taxi
- Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus
- Fly from Minneapolis–Saint Paul International Airport (MSP) to General Mitchell International Airport (MKE)plane MSP - MKE
- Take the taxi from Teutonia & Good Hope to Graftontaxi
5h 21m$683–1,098Fly Rochester to Chicago O'Hare International Airport, bus
- Fly from Rochester (RST) to Chicago O'Hare International Airport (ORD)plane RST - ORD
- Take the bus from Chicago to Milwaukee Intermodal Stationbus
6h 43m$79–341
Rochester (RST) to General Mitchell International Airport (MKE) flights
Comparing Your Travel Options
The cheapest way to get from Mayo Clinic to Grafton is to drive which costs $45 - $70 and takes 4h 59m.
The fastest way to get from Mayo Clinic to Grafton is to drive which takes 4h 59m and costs $45 - $70.
No, there is no direct bus from Mayo Clinic to Grafton. However, there are services departing from Rochester and arriving at Service Road & Schroeder via N5 & Clybourn. The journey, including transfers, takes approximately 7h 9m.
The distance between Mayo Clinic and Grafton is 303 miles. The road distance is 256.8 miles.
The best way to get from Mayo Clinic to Grafton without a car is to bus which takes 7h 9m and costs $95 - $140.
It takes approximately 7h 9m to get from Mayo Clinic to Grafton, including transfers.
Mayo Clinic to Grafton bus services, operated by Jefferson Lines, depart from Rochester station.
The best way to get from Mayo Clinic to Grafton is to bus which takes 7h 9m and costs $95 - $140. Alternatively, you can fly, which costs $100 - $550 and takes 6h 15m.
Mayo Clinic to Grafton bus services, operated by Jefferson Lines, arrive at Milwaukee station.
Yes, the driving distance between Mayo Clinic to Grafton is 257 miles. It takes approximately 4h 59m to drive from Mayo Clinic to Grafton.
What companies run services between Mayo Clinic, MN, USA and Grafton, WI, USA?
Jefferson Lines operates a bus from Rochester to Milwaukee once daily. Tickets cost $70–100 and the journey takes 5h 45m. Alternatively, Delta and American Airlines fly from Rochester (RST) to General Mitchell International Airport (MKE) every 4 hours.
- Website
- delta.com
Flights from Rochester to General Mitchell International Airport via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 4h 8m
- When
- Every day
- Estimated price
- $75–470
Flights from Minneapolis–Saint Paul International Airport to General Mitchell International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $85–600
- Website
- aa.com
Flights from Rochester to General Mitchell International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 4h 21m
- When
- Every day
- Estimated price
- $70–460
Flights from Rochester to Chicago O'Hare International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $35–240
- Website
- suncountry.com
Flights from Minneapolis–Saint Paul International Airport to General Mitchell International Airport
- Ave. Duration
- 1h 12m
- When
- Thursday
- Estimated price
- $85–600
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Rochester to Milwaukee
- Ave. Duration
- 5h 45m
- Frequency
- Once daily
- Estimated price
- $70–100
- Book at
- Jefferson Lines
- Adult
- $70–100
Bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airport
- Ave. Duration
- 1h
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- Groome Transportation - Rochester - MSP
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Chicago to Milwaukee Intermodal Station
- Ave. Duration
- 1h 20m
- Frequency
- Once daily
- Estimated price
- $12–20
- Website
- Greyhound
- Ave. Duration
- 24 min
- Estimated price
- $30–45
Olaa Taxi Milwaukee
- Phone
- +1 414-688-6786
- Website
- olaataxi.com
Yellow Taxi of Milwaukee
- Phone
- +1 414-281-1800
- Website
- yellowtaximke.com
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