There are 4 ways to get from Orlando to Florida Keys by plane, car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Orlando
best- Fly from Orlando (MCO) to Key West International Airport (EYW)plane MCO - EYW
2h 38m$67–652Bus to Tampa, fly
cheapest- Take the bus from Orlando Bus Station to Tampa Bus Stationbus
- Fly from Tampa (TPA) to Key West International Airport (EYW)plane TPA - EYW
4h 49m$64–354Drive 370.8 mi
- Drive from Orlando to Key Westcar 370.8 mi
7h 44m$68–98Fly from Orlando Sanford
- Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane SFB - EYW
1h 48m$96–333
Orlando (MCO) to Key West International Airport (EYW) flights
Comparing Your Travel Options
The cheapest way to get from Orlando to Florida Keys is to drive which costs $65 - $100 and takes 7h 44m.
The fastest way to get from Orlando to Florida Keys is to fly which takes 1h 48m and costs $95 - $340.
The distance between Orlando and Florida Keys is 287 miles. The road distance is 372.9 miles.
It takes approximately 2h 38m to get from Orlando to Florida Keys, including transfers.
Yes, the driving distance between Orlando to Florida Keys is 373 miles. It takes approximately 7h 44m to drive from Orlando to Florida Keys.
There are 969+ hotels available in Florida Keys.
What companies run services between Orlando, FL, USA and Florida Keys, Monroe County, FL, USA?
Breeze Airways and American Airlines fly from Orlando (MCO) to Key West International Airport (EYW) twice daily.
- Website
- flybreeze.com
Flights from Orlando to Key West International Airport
- Ave. Duration
- 1h 23m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $65–650
Flights from Tampa to Key West International Airport
- Ave. Duration
- 1h 14m
- When
- Every day
- Estimated price
- $50–330
- Website
- allegiantair.com
Flights from Orlando Sanford to Key West International Airport
- Ave. Duration
- 1h 14m
- When
- Friday, Thursday, Sunday, and Monday
- Estimated price
- $35–260
- Website
- aa.com
Flights from Orlando to Key West International Airport via Miami
- Ave. Duration
- 3h 5m
- When
- Every day
- Estimated price
- $35–250
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Orlando Bus Station to Tampa Bus Station
- Ave. Duration
- 1h 35m
- Frequency
- Every 4 hours
- Estimated price
- $12–19
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Orlando Bus Station to Tampa Bus Station
- Ave. Duration
- 3h 5m
- Frequency
- Once daily
- Estimated price
- $13–22
- Website
- Greyhound
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