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How to get fromIndianapolis to Mayo Clinicby plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Amtrak, Greyhound)

Find Transport to Mayo Clinic

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There are 7 ways to get from Indianapolis to Mayo Clinic by plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Indianapolis (IND) to Rochester (RST)plane plane IND - RST
    7h
    $73–462

  2. Bus via Milwaukee

    1. Take the bus from Indianapolis to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    13h 8m
    $110–164

  3. Train, bus

    1. Take the train from Indianapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    16h 4m
    $356–556

  4. Drive  526.1 mi

    1. Drive from Indianapolis to Mayo Cliniccar car 526.1 mi
    8h 54m
    $96–139

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Indianapolis (IND) to Minneapolis–Saint Paul International Airport (MSP)plane plane IND - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 44m
    $552–1,052

  6. Bus

    1. Take the bus from Indianapolis Union Station to Chicago Union Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h 26m
    $105–177

  7. Train, bus via Madison

    1. Take the train from Indianapolis to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    14h 46m
    $183–296

Indianapolis to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration13h 8mAverage Duration
Ticket$110Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Indianapolis to Mayo Clinic.ExpandLaunch map view
  • Distance: 455.9 mi
  • Duration: 7h

What companies run services between Indianapolis, IN, USA and Mayo Clinic, MN, USA?

Delta and American Airlines fly from Indianapolis (IND) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Indianapolis to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 13h 8m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

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