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How to get fromHarrisburg, Pa to Knoxvilleby plane, train, bus, car, or bus (Flixbus)

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There are 5 ways to get from Harrisburg, Pa to Knoxville by plane, train, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Harrisburg International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS)plane plane MDT - TYS
    5h 45m
    $196–922

  2. Drive  537 mi

    cheapest
    1. Drive from Harrisburg, Pa to Knoxvillecar car 537 mi
    9h
    $98–142

  3. Train, bus

    1. Take the train from Harrisburg to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    17h 6m
    $244–326

  4. Train to Philadelphia International Airport, fly

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS)plane plane PHL - TYS
    5h 42m
    $293–1,260

  5. Bus

    1. Take the bus from Harrisburg Bus Station to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    21h 45m
    $132–164

Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS) flights

Calendar94Weekly Planes
Duration4h 58mAverage Duration
Ticket$139Cheapest Price
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Comparing Your Travel Options

Map of how to get from Harrisburg, Pa to Knoxville.ExpandLaunch map view
  • Distance: 519 mi
  • Duration: 5h 45m

What companies run services between Harrisburg, Pa, PA, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Harrisburg Bus Station to Knoxville Station Hall of Fame via New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 21h 45m.

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