There are 9 ways to get from Hamilton to Mayo Clinic by bus, plane, bus (Flixbus), train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Toronto Pearson International Airport, fly to Rochester
best- Take the bus from King St. W. @ Summers Ln. to Pearson International Airport Terminal 1bus
- Fly from Toronto Pearson International Airport (YYZ) to Rochester (RST)plane YYZ - RST
8h 51m$74–400Bus
- Take the bus from Hamilton GO Centre Bus to Square Onebus 40 / ...
- Take the bus from Mississauga to Detroit Bus Stationbus
- Take the bus from Detroit Bus Station to Milwaukee Intermodal Stationbus
- Take the bus from Milwaukee to Rochesterbus
23h 36m$162–248Train, bus via Madison
- Take the train from Aldershot to Buffalotrain
- Take the train from Buffalo Depew Station to Chicago Union Stationtrain
- Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus
- Take the bus from Madison to Rochesterbus
26h 16m$390–745Drive 818.3 mi
- Drive from Hamilton to Mayo Cliniccar 818.3 mi
13h 39m$188–271Bus to Toronto Pearson International Airport, fly to Minneapolis–Saint Paul International Airport, bus
- Take the bus from King St. W. @ Summers Ln. to Pearson International Airport Terminal 1bus
- Fly from Toronto Pearson International Airport (YYZ) to Minneapolis–Saint Paul International Airport (MSP)plane YYZ - MSP
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
8h 38m$518–1,160Train, bus to Buffalo Niagara International Airport, fly to Rochester
- Take the train from West Harbour GO to Niagara Falls GOtrain
- Take the bus from Niagara Falls to Buffalobus
- Fly from Buffalo Niagara International Airport (BUF) to Rochester (RST)plane BUF - RST
11h 52m$99–516Train, bus to Buffalo Niagara International Airport, fly to Minneapolis–Saint Paul International Airport, bus
- Take the train from West Harbour GO to Niagara Falls GOtrain
- Take the bus from Niagara Falls to Buffalobus
- Fly from Buffalo Niagara International Airport (BUF) to Minneapolis–Saint Paul International Airport (MSP)plane BUF - MSP
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
10h 38m$168–646Bus via Kitchener
- Take the bus from Hamilton GO Centre Bus to Victoria St. N. @ Bingemans Centre Dr.bus 17
- Take the bus from Kitchener to Detroit Bus Stationbus
- Take the bus from Detroit Bus Station to Milwaukee Intermodal Stationbus
- Take the bus from Milwaukee to Rochesterbus
24h 9m$168–246Train, bus
- Take the train from Aldershot to Buffalotrain
- Take the train from Buffalo Depew Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to St. Paul-Minneapolistrain
- Take the bus from St. Paul to Rochesterbus
27h 14m$563–1,005
Hamilton to Mayo Clinic by bus and foot
Comparing Your Travel Options
The cheapest way to get from Hamilton to Mayo Clinic is to bus which costs $160 - $250 and takes 23h 36m.
The fastest way to get from Hamilton to Mayo Clinic is to bus and fly which takes 8h 38m and costs $500 - $1,200.
No, there is no direct bus from Hamilton to Mayo Clinic. However, there are services departing from Hamilton GO Centre Bus and arriving at Rochester via Mississauga, Detroit Bus Station and Milwaukee. The journey, including transfers, takes approximately 23h 36m.
The distance between Hamilton and Mayo Clinic is 696 miles. The road distance is 823.1 miles.
The best way to get from Hamilton to Mayo Clinic without a car is to bus which takes 23h 36m and costs $160 - $250.
It takes approximately 8h 51m to get from Hamilton to Mayo Clinic, including transfers.
Hamilton to Mayo Clinic bus services, operated by GO Transit, depart from Hamilton GO Centre Bus station.
Hamilton to Mayo Clinic bus services, operated by GO Transit, arrive at Square One station.
Yes, the driving distance between Hamilton to Mayo Clinic is 823 miles. It takes approximately 13h 39m to drive from Hamilton to Mayo Clinic.
There are 77+ hotels available in Mayo Clinic.
What companies run services between Hamilton, ON, Canada and Mayo Clinic, MN, USA?
You can take a bus from Hamilton GO Centre Bus to Mayo Clinic via Square One, Mississauga, Detroit Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 23h 36m.
- Website
- delta.com
Flights from Toronto Pearson International Airport to Rochester via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 4h 42m
- When
- Every day
- Estimated price
- $65–360
Flights from Toronto Pearson International Airport to Rochester via Detroit, Minneapolis–Saint Paul International Airport
- Ave. Duration
- 8h 10m
- When
- Every day
- Estimated price
- $70–370
Flights from Toronto Pearson International Airport to Minneapolis–Saint Paul International Airport
- Ave. Duration
- 2h 26m
- When
- Every day
- Estimated price
- $75–430
Flights from Toronto Pearson International Airport to Minneapolis–Saint Paul International Airport via Detroit
- Ave. Duration
- 4h 49m
- When
- Every day
- Estimated price
- $80–440
Flights from Buffalo Niagara International Airport to Rochester via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 7h 42m
- When
- Friday and Saturday
- Estimated price
- $80–440
Flights from Buffalo Niagara International Airport to Rochester via Detroit, Minneapolis–Saint Paul International Airport
- Ave. Duration
- 7h 44m
- When
- Every day
- Estimated price
- $85–450
Flights from Buffalo Niagara International Airport to Minneapolis–Saint Paul International Airport
- Ave. Duration
- 2h 19m
- When
- Friday and Saturday
- Estimated price
- $95–550
Flights from Buffalo Niagara International Airport to Minneapolis–Saint Paul International Airport via Detroit
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- $100–550
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Minneapolis–Saint Paul International Airport via Chicago Midway
- Ave. Duration
- 4h 14m
- When
- Tuesday, Wednesday, Sunday, and Saturday
- Estimated price
- $100–550
Flights from Buffalo Niagara International Airport to Minneapolis–Saint Paul International Airport via Baltimore
- Ave. Duration
- 5h
- When
- Tuesday, Wednesday, Saturday, and Sunday
- Estimated price
- $130–650
Flights from Buffalo Niagara International Airport to Minneapolis–Saint Paul International Airport via Nashville
- Ave. Duration
- 5h
- When
- Saturday
- Estimated price
- $140–700
- Website
- aa.com
Flights from Toronto Pearson International Airport to Rochester via Chicago O'Hare
- Ave. Duration
- 5h 57m
- When
- Every day
- Estimated price
- $65–350
Flights from Buffalo Niagara International Airport to Rochester via Chicago O'Hare
- Ave. Duration
- 6h 2m
- When
- Every day
- Estimated price
- $75–430
- Website
- united.com
Flights from Toronto Pearson International Airport to Minneapolis–Saint Paul International Airport
- Ave. Duration
- 2h 12m
- When
- Every day
- Estimated price
- $75–430
Flights from Buffalo Niagara International Airport to Minneapolis–Saint Paul International Airport via Chicago O'Hare
- Ave. Duration
- 4h 52m
- When
- Every day
- Estimated price
- $100–550
Flights from Buffalo Niagara International Airport to Minneapolis–Saint Paul International Airport via Washington Dulles
- Ave. Duration
- 5h 23m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $130–650
- Website
- aircanada.com
Flights from Toronto Pearson International Airport to Minneapolis–Saint Paul International Airport
- Ave. Duration
- 2h 12m
- When
- Every day
- Estimated price
- $75–430
Flights from Buffalo Niagara International Airport to Minneapolis–Saint Paul International Airport via Chicago O'Hare
- Ave. Duration
- 4h 52m
- When
- Every day
- Estimated price
- $100–550
- Phone
- +1 888 842-7245
- Website
- VIA Rail
Train from Aldershot to Buffalo
- Ave. Duration
- 3h 25m
- Frequency
- Once daily
- Estimated price
- $21–160
- Website
- VIA Rail
- Escape
- $21–70
- Business
- $50–150
- Business Plus
- $60–160
- Economy
- $24–80
- Economy Plus
- $26–85
Train from Aldershot to Buffalo
- Ave. Duration
- 3h 25m
- Frequency
- Once daily
- Estimated price
- $21–160
- Website
- VIA Rail
- Escape
- $21–70
- Business
- $50–150
- Business Plus
- $60–160
- Economy
- $24–80
- Economy Plus
- $26–85
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Buffalo Depew Station to Chicago Union Station
- Ave. Duration
- 10h 33m
- Frequency
- Twice daily
- Estimated price
- $290–450
- Website
- Amtrak
Train from Buffalo Depew Station to Chicago Union Station
- Ave. Duration
- 10h 33m
- Frequency
- Twice daily
- Estimated price
- $290–450
- Website
- Amtrak
Train from Chicago Union Station to St. Paul-Minneapolis
- Ave. Duration
- 7h 31m
- Frequency
- 3 times a day
- Estimated price
- $220–350
- Website
- Amtrak
- Phone
- +1 888-438-6646
- Website
- GO Transit
Train from West Harbour GO to Niagara Falls GO
- Ave. Duration
- 1h 19m
- Frequency
- Twice daily
- Estimated price
- $9–12
- Website
- GO Transit
- Website
- GO Transit Schedules
- Passenger
- $9–12
Train from West Harbour GO to Niagara Falls GO
- Ave. Duration
- 1h 19m
- Frequency
- Twice daily
- Estimated price
- $9–12
- Website
- GO Transit
- Website
- GO Transit Schedules
- Passenger
- $9–12
- Phone
- +1 888-438-6646
- Website
- GO Transit
Bus from King St. W. @ Summers Ln. to Pearson International Airport Terminal 1
- Ave. Duration
- 1h 17m
- Frequency
- Every 30 minutes
- Estimated price
- $8–10
- Website
- GO Transit
- Website
- GO Transit Schedules
- Passenger
- $8–10
Bus from Hamilton GO Centre Bus to Square One
- Ave. Duration
- 55 min
- Frequency
- Every 15 minutes
- Estimated price
- $7–9
- Website
- GO Transit
- Website
- GO Transit Schedules
- Passenger
- $7–9
Bus from King St. W. @ Summers Ln. to Pearson International Airport Terminal 1
- Ave. Duration
- 1h 17m
- Frequency
- Every 30 minutes
- Estimated price
- $8–10
- Website
- GO Transit
- Website
- GO Transit Schedules
- Passenger
- $8–10
Bus from Hamilton GO Centre Bus to Victoria St. N. @ Bingemans Centre Dr.
- Ave. Duration
- 1h 59m
- Frequency
- Every 3 hours
- Estimated price
- $9–12
- Website
- GO Transit
- Website
- GO Transit Schedules
- Passenger
- $9–12
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Mississauga to Detroit Bus Station
- Ave. Duration
- 6h 5m
- Frequency
- 5 times a week
- Estimated price
- $30–55
- Schedules at
- Flixbus USA
Bus from Detroit Bus Station to Milwaukee Intermodal Station
- Ave. Duration
- 7h 40m
- Frequency
- 4 times a week
- Estimated price
- $55–85
- Schedules at
- Flixbus USA
Bus from Kitchener to Detroit Bus Station
- Ave. Duration
- 5h 20m
- Frequency
- 3 times a week
- Estimated price
- $29–45
- Schedules at
- Flixbus USA
Bus from Detroit Bus Station to Milwaukee Intermodal Station
- Ave. Duration
- 7h 40m
- Frequency
- 4 times a week
- Estimated price
- $55–85
- Schedules at
- Flixbus USA
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Milwaukee to Rochester
- Ave. Duration
- 5h 40m
- Frequency
- Once daily
- Estimated price
- $70–100
- Book at
- Jefferson Lines
- Adult
- $70–100
Bus from Madison to Rochester
- Ave. Duration
- 4h 20m
- Frequency
- Once daily
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
Bus from Milwaukee to Rochester
- Ave. Duration
- 5h 40m
- Frequency
- Once daily
- Estimated price
- $70–100
- Book at
- Jefferson Lines
- Adult
- $70–100
Bus from St. Paul to Rochester
- Ave. Duration
- 1h 25m
- Frequency
- Once daily
- Estimated price
- $28–40
- Book at
- Jefferson Lines
- Adult
- $28–40
- Phone
- +1 (866) 912 - 6224
- questions@coachusa.com
- Website
- Rockland Coaches
Bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campus
- Ave. Duration
- 3h 40m
- Frequency
- Hourly
- Estimated price
- $25–55
- Schedules at
- Rockland Coaches
- Adult
- $25–55
Bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochester
- Ave. Duration
- 1h 45m
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- Groome Transportation - Rochester - MSP
Bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochester
- Ave. Duration
- 1h 45m
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- Groome Transportation - Rochester - MSP
- Phone
- +1 800-858-8555
- Website
- Trailways
Bus from Niagara Falls to Buffalo
- Saver
- $14–19
- Flexible
- $18–35
Bus from Niagara Falls to Buffalo
- Saver
- $14–19
- Flexible
- $18–35
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